34380 Cadherin complexes recruit PIWIL2 to suppress transposons and pro-tumorigenic transformation
ABSTRACT IMPACT: This study has uncovered a novel surprising mechanism involving the epithelial adherens read more junctions and transposon regulation that can deepen our understanding of tumorigenesis.OBJECTIVES/GOALS: Recent studies show that genomic instability in 50% of tumors can be attributed to increased transposon activity, but the the reas